基于天然多糖的药物输送纳米颗粒的制备和性能
Xuelian Chen1, Lijia Liu2, Chen Shen1
1College of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316000, China.
Polymers
|June 10, 2023
概括
新型多糖纳米颗粒显示出作为向抗癌药物载体的前景. 这些RGD移植的纳米颗粒有效地将多克索鲁比传递给结肠癌细胞,抑制它们的生长.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 天然多糖在先进的药物输送系统中越来越多地使用.
- 基于多糖的纳米粒子为治疗应用提供生物相容性和可调节性质.
研究的目的:
- 开发用于向癌症治疗的新型RGD移植多糖纳米颗粒.
- 评估这些纳米颗粒的药物携带能力,pH敏感释放和细胞准效率.
主要方法:
- 一层一层的组装,使用作为模板,从NPGP核素和基多构建纳米颗粒.
- 植入RGD以传递对整合素受体的特定向.
- 对多克索鲁比的封装和体外释放研究.
- 使用HCT-116和MCF7细胞系进行细胞吸收研究.
- 在实验室对抗HCT-116细胞的抗瘤活性进行评估.
主要成果:
- RGD-(NPGP/CS) 3NPGP纳米颗粒显示出高的多克索鲁比辛封装效率 (83.23%) 和负载能力 (76.51%).
- 这些纳米粒子表现出pH敏感的药物释放特性.
- 与MCF7细胞相比,在HCT-116细胞 (高整合素αvβ3表达) 中观察到增强的向和吸收.
- 装有多克索鲁比的纳米颗粒有效抑制了HCT-116细胞的增殖.
结论:
- RGD-(NPGP/CS) 3NPGP纳米颗粒代表了针对性抗癌药物输送的有希望的平台.
- 这些纳米粒子表现出优异的药物携带能力和针对结肠癌治疗的特定向潜力.
- 进一步的开发可能会导致针对整合素过度表达瘤的新型治疗策略.
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