如何开发基于碳水化合物纳米颗粒的药物输送系统,针对大脑瘤
Vladimir E Silant'ev1,2, Mikhail E Shmelev1, Andrei S Belousov1
1Institute of Life Sciences and Biomedicine, Far Eastern Federal University, 690922 Vladivostok, Russia.
Polymers
|June 10, 2023
概括
碳水化合物纳米颗粒通过改善通过血脑屏障 (BBB) 传递药物,为脑瘤治疗提供了一个有希望的解决方案. 本综述探讨了它们的合成和治疗侵略性质瘤和质母细胞瘤的潜力.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 在瘤学瘤学.
背景情况:
- 大脑瘤由于其多种形式,有限的有效化疗和血脑屏障 (BBB) 存在重大治疗挑战.
- 纳米粒子 (1-500nm) 正在成为先进的药物输送系统,由纳米技术的进步推动.
- 基于碳水化合物的纳米粒子为分子运输提供生物相容性,生物降解性和降低毒性.
研究的目的:
- 审查碳水化合物纳米颗粒的合成和修改策略.
- 提供与碳水化合物纳米载体相关的生物和临床结果的概述.
- 突出碳水化合物纳米载体在质瘤和质母细胞瘤中向药物输送的潜力.
主要方法:
- 文献综述专注于碳水化合物纳米粒子的合成和改造.
- 对这些纳米载体的生物活性和临床应用现有研究的分析.
- 探索生物聚合物体纳米材料的设计和制造方面的挑战.
主要成果:
- 碳水化合物纳米颗粒显示出克服BBB的潜力,增强向脑瘤的药物输送.
- 这些纳米载体表现出良好的生物相容性和生物降解性,最大限度地降低了系统性毒性.
- 该审查综合了当前关于制造技术和治疗疗效的知识.
结论:
- 基于碳水化合物的纳米颗粒代表了在神经瘤学中向药物输送的有希望的平台.
- 对它们的设计和制造进行进一步的研究对于临床翻译至关重要.
- 这些纳米载体具有显著的潜力,可以改善高度质瘤和质母细胞瘤的治疗结果.
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