咖啡提取物的急性认知表现和情绪影响:一项随机,双盲,安慰剂控制的交叉研究,在健康人群中进行
Philippa A Jackson1, Charlotte Kenney1, Joanne Forster1
1Brain Performance and Nutrition Research Centre, Northumbria University, Newcastle upon Tyne NE1 8ST, UK.
Nutrients
|June 10, 2023
概括
低剂量的咖啡提取物对健康成年人的认知或情绪没有益处. 100毫克的剂量意外地增加了精神疲劳,减少了注意力准确性,建议在单独使用咖啡时谨慎使用.
科学领域:
- 营养神经科学 营养神经科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 咖啡提取物,富含基酸,被探索为情绪和认知增强.
- 以前的研究经常将其与其他化合物结合在一起,限制了对其孤立作用的理解,特别是在低剂量下.
研究的目的:
- 为了研究低剂量和中等剂量的咖啡提取物对认知功能和情绪的影响.
- 评估隔离咖啡提取物在健康成年人的影响.
主要方法:
- 一项随机,双盲,安慰剂控制的交叉研究,涉及72名健康成年人 (18-49岁).
- 参与者饮用了含有100毫克或300毫克咖啡提取物 (40%酸) 或75毫克咖啡因的饮料.
- 认知,情绪和主观能量在基线,摄入后60分钟和120分钟被评估.
主要成果:
- 与安慰剂相比,300毫克的剂量没有显著影响.
- 100毫克的剂量导致精神疲劳增加 (p=0.025) 和持续注意力精度下降 (p=0.003) 在60分钟.
- 对于任何剂量,都没有观察到对情绪或主观能量的显著影响.
结论:
- 低剂量 (100毫克) 咖啡提取物对特定的认知任务表现出暂时的负面影响.
- 中等剂量 (300毫克) 咖啡提取物没有产生显著的认知或情绪影响.
- 该研究表明,在低至中等剂量中,孤立的咖啡提取物可能不会带来好处,并可能会损害认知能力;为了有效性,可能需要更高的剂量.
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