饮食和体育活动对NAFLD队列的协同效应:代谢学概况和临床变量评估
Francesco Maria Calabrese1, Giuseppe Celano1, Caterina Bonfiglio2
1Department of Soil, Plant and Food Science, University of Bari Aldo Moro, 70126 Bari, Italy.
Nutrients
|June 10, 2023
概括
饮食和运动相结合,通过改变肠道微生物群和挥发性有机化合物 (VOCs),显著改善非酒精性脂肪性肝病 (NAFLD). 这种方法显示出不仅仅是用于NAFLD管理的协同效应.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 正在随着肥胖流行病而增加.
- 卡路里限制和体力活动可以减轻NAFLD的进展.
- 肝功能和肠道微生物群是相互联系的.
研究的目的:
- 为了评估联合饮食和体育活动与单独体育活动对NAFLD患者的影响.
- 探索便挥发性有机化合物 (VOC),临床变量和肠道微生物群组成之间的关系.
主要方法:
- 46名NAFLD患者被分为两组:饮食加体育活动和单体育活动.
- 便代谢分析分析了挥发性有机化合物 (VOC).
- 16S rRNA基因测序确定了肠道微生物群的相对丰度.
主要成果:
- 在VOC和临床参数之间发现了显著的相关性.
- 还确定了VOCs和肠道微生物群种群之间的相关性.
- 乙烯烯酸,氨酸丁烯,甲基烯酸和5-二,6-甲基水平在联合干预过程中发生了显著变化.
- 5 - 二,6 - 甲基与Sanguinobacteroides,Oscillospiraceae-UCG002和Ruminococcaceae UCG010.010之间显示出正相关性.
结论:
- 地中海饮食和体育活动的结合对NAFLD患者产生了协同作用.
- 通过这种联合干预,特定的VOCs受到调节,这表明与肠道微生物群变化的联系.
- 本研究突出了NAFLD管理的潜在生物标志物和治疗目标.
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