氧化平衡得分和发生情况之间的反向关联 2 型糖尿病
Yu-Jin Kwon1, Hye-Min Park2, Jun-Hyuk Lee3,4
1Department of Family Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin 16995, Republic of Korea.
保持健康的氧化平衡得分 (OBS) 与患2型糖尿病 (T2DM) 的风险降低有关. 这表明,强调抗氧化剂的生活方式选择可能有助于预防T2DM.
科学领域:
- 营养流行病学 营养流行病学
- 代谢性疾病研究研究
- 氧化压力研究 研究 氧化压力研究
背景情况:
- 2型糖尿病 (T2DM) 是一个重要的全球健康问题.
- 饮食和运动等生活方式因素对于T2DM预防至关重要.
- 氧化平衡评分 (OBS) 整合了亲和抗氧化剂暴露,以评估整体氧化状态.
研究的目的:
- 研究氧化平衡得分 (OBS) 与2型糖尿病发病率 (T2DM) 之间的关联.
- 评估OBS作为T2DM风险的潜在生物标志物在大型前队列中.
主要方法:
- 韩国基因组和流行病学研究 (KoGES) 7369名参与者的数据分析.
- 前性队列研究设计,平均随访时间为13.6年.
- 用性别特定的考克斯比例危险回归模型计算了OBS类动物T2DM发病率的危险比率 (HR) 和95%置信区间 (CI).
主要成果:
- 在随访期间,908名男性和880名女性患有T2DM.
- 在男性中,T2DM的完全调整后HR为0.83 (95% CI:0.70-0.99) 对于最高的OBS三位数与最低的OBS三位数相比.
- 在女性中,T2DM的完全调整后HR为0.78 (95% CI:0.65-0.94) 对于最高的OBS三位数与最低的相比.
结论:
- 较高的氧化平衡得分 (OBS) 与患2型糖尿病 (T2DM) 的风险降低有关.
- 促进增强抗氧化特性的生活方式的修改,可以作为T2DM的有效预防策略.
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