与便微生物群相关的饮食和皮肤中的高级糖化终产物 (AGEs):鹿特丹研究
Jinluan Chen1,2, Djawad Radjabzadeh1, Carolina Medina-Gomez1
1Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.
Nutrients
|June 10, 2023
概括
这项研究发现,饮食中摄入的高级糖化终产品 (AGEs) 或皮肤AGE与肠道微生物群的整体组成之间没有强烈的联系. 一些特定的细菌属显示了名义关联,表明需要进一步研究的潜在相互作用.
科学领域:
- 微生物组研究的研究.
- 代谢学 代谢学 代谢学
- 衰老和疾病的作用
背景情况:
- 先进的糖化终产品 (AGEs) 与与年龄有关的疾病有关.
- 在一般人群中,饮食中的AGE (dAGEs),组织AGE和肠道微生物群之间的关系尚不清楚.
研究的目的:
- 调查饮食和组织AGE与肠道微生物群组成之间的关联.
- 利用基于人口的鹿特丹研究,使用皮肤AGE (SAF) 作为组织积累的标记物和便微生物群进行肠道微生物分析.
主要方法:
- 使用食物频率调查问卷量化了三种AGE (CML,MGH1,CEL) 的饮食摄入量.
- 测量皮肤AGE (SAF) 和排序便微生物群 (16SrRNA) 在平均5.7年后.
- 在1052名 (dAGEs) 和718名 (SAF) 参与者中使用多重线性回归模型分析了协会.
主要成果:
- 在dAGEs或SAF与便微生物群的总体α-多样性或β-不相似性之间没有发现显著的关联.
- 观察到dAGEs与特定属 (例如,Coprococcus,Dorea,Blautia) 之间以及SAF和乳杆菌丰度之间的名义关联.
- 在多次测试校正后,没有微生物途径显示出统计学上显著的关联.
结论:
- 该研究没有确定习惯性dAGE,皮肤AGE和整体肠道微生物群组成之间的明确联系.
- 标称关联表明肠道微生物群和AGE代谢之间的潜在相互作用,需要验证.
- 需要进一步的研究来探索肠道微生物群如何影响dAGE对健康的影响.
更多相关视频
07:15An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
Published on: July 31, 2019
9.7K
06:26Analyzing the Permeability of the Blood-Brain Barrier by Microbial Traversal through Microvascular Endothelial Cells
Published on: February 14, 2020
15.8K
相关概念视频
Development of Human Microbiota
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
The Skin Microbiota
The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
Dysbiosis of the Gut Microbiota
The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
