肠道微生物群对短肠综合征和肠-大脑轴的调节
Jasmine Carter1, Jeffery Bettag1, Sylvia Morfin1
1Department of Pediatrics, Saint Louis University, Saint Louis, MO 63104, USA.
Nutrients
|June 10, 2023
概括
短肠综合征 (SBS) 涉及肠道功能障碍. 本综述探讨了肠道微生物群如何影响SBS,肠-大脑轴 (GBA) 和潜在的微生物组改变疗法.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
- 神经胃肠病学 神经胃肠病学
背景情况:
- 短肠综合征 (SBS) 是一种由肠道长度或功能减少而导致并发症的情况.
- SBS并发症的病因尚未完全理解,使肠道适应成为一个关键的研究领域.
- 人们越来越认识到肠道微生物组在SBS进展和系统性影响中的作用,尽管定义一个"健康"的微生物组仍然具有挑战性.
研究的目的:
- 审查肠道微生物群在短肠综合征 (SBS) 中的作用.
- 为了检查肠道微生物在SBS中对肠-大脑轴 (GBA) 的影响.
- 探索SBS中调节肠道微生物组的治疗潜力.
主要方法:
- 关于SBS肠道微生物群组成研究的文献综述.
- 对SBS中小肠细菌过度生长 (SIBO) 的研究分析.
- 检查关于肠-大脑轴 (GBA) 和其由肠道微生物调节的数据.
主要成果:
- 在SBS中微生物的转变是非常可变的,受切除部位,残留肠道特征和SIBO的影响.
- 肠道微生物在肠道和中枢神经系统 (GBA) 之间的双向通信中发挥作用.
- 了解这些微生物动态对于管理SBS至关重要.
结论:
- 肠道微生物组显著影响SBS进展和相关并发症.
- 准肠道微生物组为SBS提供了潜在的治疗策略.
- 对SBS-微生物组-GBA相互作用进行进一步的研究是必要的,以获得临床进展.
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