血清基本元素和癌症诊断后的生存
Jan Lubiński1,2, Marcin R Lener1, Wojciech Marciniak2
1Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland.
血液中和的较高水平与癌症患者更好的生存率有关. 相反,高铜水平与患有乳腺癌,前列腺癌,肺癌和喉癌的个体的死亡风险增加有关.
科学领域:
- 在瘤学瘤学.
- 营养生物化学 营养生物化学
- 流行病学 流行病学
背景情况:
- 血清元素水平,特别是 (Se), (Zn) 和铜 (Cu),可能会影响癌症患者的预后.
- 了解这些关联可以为支持性护理策略提供信息.
研究的目的:
- 研究乳腺癌,前列腺癌,肺癌和喉癌患者血清Se,Zn和Cu水平与全因死亡率之间的关系.
- 确定这些微量元素是否可以作为癌症结果的预后生物标志物.
主要方法:
- 在波兰斯切辛对1475名癌症患者 (乳腺,前列腺,肺,喉) 的前性研究.
- 诊断后和治疗前收集的血清样本用于元素分析.
- 卡普兰-梅尔曲线和考克斯回归分析用于评估与所有原因死亡率的关联,平均随访时间为6.0-9.8年.
主要成果:
- 高血清 (Se) 水平与全因死亡率降低有关 (HR = 0.66).
- 高血清 (Zn) 水平也与所有原因死亡率的降低有关 (HR = 0.55).
- 高血清铜 (Cu) 水平与所有原因死亡率的增加显著相关 (HR = 1.91).
结论:
- 血清和水平与癌症患者的预后改善有关.
- 血清铜水平升高与预后较差和死亡率增加有关.
- 这些血清元素可以作为各种癌症类型的重要预后指标.
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