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与端粒长度和端粒酶复合体组件相关的脂蛋白粒子配置文件

Nil Novau-Ferré^1,2,3, Melina Rojas^1,2,3, Laia Gutierrez-Tordera^1,2,3

¹Nutrition and Metabolic Health Research Group, Department of Biochemistry and Biotechnology, Rovira i Virgili University (URV), 43201 Reus, Spain.

|June 10, 2023

概括

脂蛋白样本与前糖尿病患者的端粒长度和与端粒相关的基因表达有关. 特定的HDL粒子大小与更短的端粒和TERT和WRAP53.3的减少表达相关.

科学领域:

分子生物学分子生物学
老年学是指老年学的学科.
心血管研究研究心血管研究

背景情况:

端粒长度 (TL) 是衰老和与年龄有关的疾病的生物标志物.
氧化应激和炎症加速端粒缩短和细胞衰老.
脂蛋白功能包括抗炎和促炎性质,但它们与端粒动态的联系还未得到充分研究.

研究的目的:

为了研究脂蛋白分片和端粒长度 (TL) 之间的关联.
为了检查脂蛋白分片与与端粒酶活性相关基因的表达之间的关系,TERT和WRAP53.
在糖尿病前患者中,确定与端粒相关参数相关的特定脂蛋白配置文件.

主要方法:

这项研究包括54名来自EPIRDEM队列的糖尿病前期患者.
用高斯线性回归与拉索惩罚来分析12个脂蛋白子类与TL,TERT和WRAP53表达之间的关联.
分析对包括年龄,性别,BMI,失脂症,他类药物的使用和体育活动在内的共同变量进行了调整.

主要成果:

鉴定出一个显著的脂蛋白概况,与TL (r=0.347,p=0.010),TERT (r=0.316,p=0.020) 和WRAP53 (r=0.379,p=0.005) 相关.
中小的HDL粒子与较短的端粒和较低的TERT/WRAP53表达相关.
大型HDL颗粒与较长的端粒和较低的WRAP53表达有关,但不是TERT.

结论:

脂蛋白概况与端粒长度和TERT和WRAP53.3的表达有显著的关联.
特定的HDL颗粒大小显示出与端粒动态的明显关系.
这些发现表明,在评估慢性疾病风险时,应考虑脂蛋白配置文件.

关键词:

这里是 TERTTT.在WRAP53中使用WRAP53.脂蛋白子类是脂蛋白子类中的一个.端粒酶复合物的组成部分端粒的长度端粒的长度

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