一项关于慢性病患者营养状况评估新方法的探索性研究
Yayong Luo1,2, Hui Huang1,2, Qian Wang1
1Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, National Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing 100853, China.
Nutrients
|June 10, 2023
概括
在慢性病 (CKD) 中评估营养不良是复杂的. 一种名为脏iNUT的新工具显示出对CKD患者的营养查有前途,其综合指标为营养不良提供了高诊断效率.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 临床营养学 临床营养学
- 生物化学 生物化学
背景情况:
- 营养不良显著恶化慢性病 (CKD) 的结果.
- 目前的CKD营养评估方法复杂,限制了临床使用.
- 准确和有效的营养状况评估对于CKD患者管理至关重要.
研究的目的:
- 探索和评估一个新的营养评估工具,脏住院患者营养查工具 (脏iNUT),用于CKD患者 (阶段1-5).
- 评估脏iNUT与主观全球评估 (SGA) 和蛋白质能量浪费等既定方法的一致性.
- 识别CKD营养不良的风险因素,并开发一个综合诊断模型.
主要方法:
- 一个卡帕测试分析了脏iNUT,SGA和蛋白质能量浪费之间的一致性.
- 在161名CKD患者中,逻辑回归确定了营养不良的风险因素.
- 一个接收器操作特征 (ROC) 曲线评估了组合指标的诊断效率.
主要成果:
- 根据SGA,营养不良的患病率为19.9%.
- 脏iNUT显示了与SGA的中度一致性以及与蛋白质能量浪费的一般一致性.
- 确定了关键的营养不良风险因素:年龄大于60岁,中性粒细胞-淋巴细胞比例高,转激素低,相角低,体脂百分比低.
- 综合指标模型实现了ROC曲线下的面积为0.89 (p < 0.001).
结论:
- 脏iNUT在CKD患者的营养查中显示出良好的特异性,尽管敏感性需要改进.
- 高龄,中性粒细胞-淋巴细胞比率升高,低转移素,低相角和低体脂是CKD营养不良的重要危险因素.
- 这些指标的组合提供了一种高效,客观和简单的方法来诊断CKD患者的营养不良.
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