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二氧化纳米颗粒:对发育和男性生殖系统的影响

Elena Maria Scalisi¹, Roberta Pecoraro¹, Antonio Salvaggio²

¹Department of Biological, Geological and Environmental Science, University of Catania, 95124 Catania, Italy.

Nanomaterials (Basel, Switzerland)

|June 10, 2023

概括

二氧化纳米粒子 (TiO2-NPs) 没有影响斑马鱼胚胎发育. 然而,TiO2-NPs改变了男性生殖器官,导致氧化应激和潜在的内分泌干扰,表明男性生殖系统的风险.

科学领域:

环境毒理学环境毒理学
纳米技术纳米技术
生殖生物学生殖生物学

背景情况:

二氧化纳米颗粒 (TiO2-NPs) 由于其小小的尺寸被广泛使用,导致生物体的吸收增加.
这些纳米粒子可以分布到包括生殖系统在内的各种器官,引发了对潜在毒性的担忧.
斑马鱼 (Danio rerio) 是一个适合研究纳米粒子对发育和繁殖的影响的模型生物.

研究的目的:

评估TiO2-NPs对斑马鱼胚胎发育的毒性影响.
调查TiO2-NPs对斑马鱼雄性生殖系统的影响.
探索TiO2-NPs的潜在内分泌干扰活性.

主要方法:

斑马鱼胚胎和成年雄性暴露于TiO2-NP,其度为1 mg/L,2 mg/L和4 mg/L.
监测胚胎发育是否存在干扰.
用免疫光和qRT-PCR分析男性生殖器官的形态/结构变化,以评估氧化应激,SHBG和与雄激素相关的基因表达.

主要成果:

TiO2-NPs并没有显著干扰斑马鱼胚胎发育.
暴露于TiO2-NPs会导致男性生殖腺的形态和结构变化.
氧化应激和性激素结合球蛋白 (SHBG) 的生物标志物呈阳性,与转化相关的基因表达增加,表明内分泌干扰和雄激素活性.

结论:

TiO2-NP似乎没有影响斑马鱼胚胎发育.
在斑马鱼中,TiO2-NPs对雄性生殖系统具有毒性,诱导氧化应激并改变生殖激素通路.
这些发现表明,TiO2-NP可能充当具有雄激素活性的内分泌干扰剂,对男性生殖健康构成风险.

关键词:

丹尼奥·雷里奥 (Danio Rerio) 是一个这种TiO2-NPs是什么?胚胎发育过程中的胚胎.内分泌系统内分泌系统男人的不孕不育症.测试测试测试

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