解读雌激醇和雌激素受体对认知功能的影响:图书统计分析和新兴研究趋势
Min Wu1, Shujie Lou1
1Key Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sports, Shanghai, China (mainland).
概括
雌激醇 (E2) 和雌激素受体 (ERs) 显著影响认知. 研究强调了雌激素替代疗法 (ERT) 和海马的关键年龄窗口.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 图书统计学 图书统计学
背景情况:
- 雌激醇 (E2) 和其雌激素受体 (ERs) 影响认知,推动人们对优化雌激素替代疗法 (ERT) 的兴趣.
- 需要进行系统的文献计量分析来绘制连接E2/ER和认知功能的研究格局.
- 了解这些联系对于制定有效的ERT战略和减轻不利影响至关重要.
研究的目的:
- 对有关雌激醇,雌激素受体和认知的出版物进行文献计量分析.
- 确定研究趋势,关键主题和在该领域有影响力的贡献者.
- 绘制关于E2/ERs和认知功能研究的演变和当前热点的地图.
主要方法:
- 使用CiteSpace软件分析了来自Web of Science核心集合的3502个出版物.
- 根据引用数,中心性,西格玛指数和爆发强度来识别高度共同引用的文章.
- 关键词分析以确定研究集群和主题,以及国家,机构和作者贡献.
主要成果:
- 关键的研究热点包括ERT的"临界年龄窗口"假设,海马体衍生的E2,G蛋白合雌激素受体 (GPER) 调解,和ER交叉通话.
- 美国在出版物方面处于领先地位,威斯康星大学是主要机构.
- 苏格兰和斯坦福大学显示出高度的中心性;有影响力的作者包括伍利CS,Frick KM,Tuscher JJ和埃斯佩兰MA.
结论:
- 该研究确定了与E2和ERs相关的认知增强的当前研究前沿和潜在的治疗目标.
- 预计未来的研究将集中在E2/ERs,海马体,记忆类型和性别/受体特异性之间的相互作用上.
- 研究结果为未来对E2/ER用于认知改善的研究提供了路线图.
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