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治疗与脏,甲状腺和副甲状腺功能之间的关联:一项对6659名双相情感障碍患者的队列研究
Anne Christine Wiuff1,2, Christopher Rohde1,2, Botilla Dalsgaard Jensen1,2
1Department of Affective Disorders, Aarhus University Hospital-Psychiatry, Aarhus, Denmark.
Bipolar disorders
|June 10, 2023
概括
治疗双相情感障碍的治疗很少导致严重的脏或内分泌问题,尽管监测增加. 长期使用的研究可能会受到检测偏差的影响,因为检测率更高.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 内分泌学 在内分泌学.
- 精神病学是一个精神病学.
背景情况:
- 是对双相情感障碍的关键治疗方法.
- 之前关于的不良影响的研究受到人口选择和随访持续时间的限制.
- 对于对脏和内分泌功能的影响存在担忧.
研究的目的:
- 为了研究双相情绪障碍患者的长期脏和内分泌结果,用治疗.
- 为了比较使用者和匹配的参考组之间的疾病发病率和生物化学标记物变化.
主要方法:
- 一项对双相情感障碍患者进行血清测量的队列研究 (2013-2022年).
- 包括1646名使用者和5013名匹配的参考患者.
- 评估,甲状腺和副甲状腺疾病的诊断,以及使用回归分析的关键生化标志物 (肌素,eGFR,TSH,PTH,).
主要成果:
- 使用者表现出降低TSH和eGFR,稳定PTH和增加的趋势.
- 在使用者中观察到脏,甲状腺和副甲状腺疾病的增加率 (HR 1.07-11.22).
- 严重的结局是罕见的 (例如,CKD 0.6%),使用者接受的血液检测显著增加,这表明潜在的检测偏差.
结论:
- 严重不良的脏和内分泌结果在治疗中很罕见.
- 对长期治疗的观察性研究容易产生检测偏差.
- 在使用者中增加监测可能会增加感知风险.
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