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相关概念视频

Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

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The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
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Mitochondrial Membranes01:45

Mitochondrial Membranes

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A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
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The Electron Transport Chain01:30

The Electron Transport Chain

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The electron transport chain or oxidative phosphorylation is an exothermic process in which free energy released during electron transfer reactions is coupled to ATP synthesis. This process is a significant source of energy in aerobic cells, and therefore inhibitors of the electron transport chain can be detrimental to the cell's metabolic processes.
Inhibitors of the electron transport chain
Rotenone, a widely used pesticide, prevents electron transfer from Fe-S cluster to ubiquinone or Q...
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Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
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化物诱导的线粒体功能障碍及其干预方法.

Sachindra Kumar1, Smita Shenoy2, Ravindra Shantakumar Swamy3

  • 1National Institute of Pharmaceutical Education and Research, Hajipur, Industrial Area Hajipur, Vaishali, 844102, India.

Biological trace element research
|June 10, 2023
PubMed
概括

长时间的化物暴露会通过诱导线粒体功能障碍,氧化应激和炎症而损害人类健康. 这篇评论探讨了化物.

关键词:
抗氧化剂是一种抗氧化剂.细胞灭亡 (apoptosis) 是一种死亡的过程.光症是一种光症.线粒体动力学的动态这就是ROSOS ROS.

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Experimental Protocol for Detecting Mitochondrial Function in Hepatocytes Exposed to Organochlorine Pesticides
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科学领域:

  • 环境毒理学环境毒理学
  • 细胞生物学 细胞生物学
  • 线粒体研究的研究.

背景情况:

  • 化物无处不在,饮用水是主要的暴露途径.
  • 低化物水平有利于骨和牙健康,但长期暴露是有害的.
  • 临床前研究将化物毒性与氧化应激,炎症和亡联系起来.

研究的目的:

  • 审查化物对线粒体动力学,线粒体和生物生成的影响.
  • 为了阐明化物诱导的线粒体毒性和功能障碍的途径.
  • 讨论针对化物毒性的治疗策略.

主要方法:

  • 对化物毒性临床前研究的文献综述.
  • 对化物对线粒体影响的分子机制的分析.
  • 检查针对化物诱导的细胞损伤的治疗干预措施.

主要成果:

  • 化物毒性与线粒体功能障碍有关,包括改变的动态和受损的线粒体.
  • 线粒体在反应性氧物种 (ROS) 生产中的作用是化物诱导的细胞损伤的核心.
  • 线粒体DNA净化和调节的线粒体动力学对于细胞生存至关重要.

结论:

  • 化物暴露会诱导显著的线粒体毒性和细胞功能障碍.
  • 了解这些机制是开发有效治疗化物中毒的关键.
  • 植物化学品和药理学剂通过管理ROS和细胞过程,有望减轻化物的不良影响.