用不同溶剂激光去除青和煤炭 试验室内研究
Huda Mahmood Al-Attar1, Maeda H Mohammad2, Ali Hussein Alwan2
1Environmental Engineering Department, College of Engineering, University of Baghdad, Baghdad, Iraq. Huda.al-attar@coeng.uobaghdad.edu.iq.
Lasers in medical science
|June 10, 2023
概括
液体中脉冲激光切除 (PLAL) 从青和煤炭中产生碳纳米聚合物. 这些材料对乳腺癌细胞 (MCF7) 具有显著的抗癌作用,对正常细胞有低毒性 (REF).
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 乳腺癌是妇女死亡的主要原因.
- 液体中脉冲激光切除 (PLAL) 为生产纳米聚合物提供了一种绿色,具有成本效益的方法.
- 纳米粒子在向癌症治疗方面表现有前途.
研究的目的:
- 评估通过PLAL制备的青和煤纳米聚合物的细胞毒性.
- 评估对人类乳腺癌 (MCF7) 和正常 (REF) 细胞系的疗效.
- 探索不同溶剂对纳米合体特性和作用的影响.
主要方法:
- 使用PLAL与1.06μm光纤激光器合成了青和煤炭的纳米聚合物.
- 使用了包括乙醇,DMSO,PBS和DW在内的各种溶剂.
- 在实验室中对MCF7和REF细胞系进行了细胞毒性测试.
主要成果:
- 乙醇和DMSO中的青纳米聚合物对MCF7细胞表现出显著的细胞毒性作用 (分别抑制了62.1%和50.5%的生长).
- DMSO中的煤纳米聚合物也显示出明显的增长抑制 (59.5%) 对MCF7细胞.
- 青和煤纳米聚合物都显示出对正常REF细胞系的低细胞毒性.
结论:
- 在有机溶剂中使用PLAL合成的碳基纳米聚合物对乳腺癌细胞具有显著的抗癌特性.
- 这些材料具有良好的安全性,对正常细胞的毒性最小.
- 进一步的体内研究是有必要的,以探索治疗潜力.
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