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Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications
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含有银的生物材料用于生物医学硬组织植入物.

Huifeng Shao1,2,3,4, Tao Zhang1, Youping Gong1

  • 1School of Mechanical Engineering, Hangzhou Dianzi University, Hangzhou, 310018, China.

Advanced healthcare materials
|June 10, 2023
PubMed
概括

由于银的有效性和耐药性较低的发展,银在对抗植入物相关的细菌感染方面表现有前途. 然而,其细胞毒性需要仔细整合到生物材料中,以便在骨再生中安全临床使用.

关键词:
抗菌剂是一种抗菌剂.生物材料是一种生物材料.涂料,涂料上的涂料.兴奋剂的使用 兴奋剂的使用银,银,银,银,银,银,银,银,银,银,银,银,银,银,银,银

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科学领域:

  • 生物材料科学 生物材料科学
  • 传染性疾病 传染性疾病
  • 纳米技术纳米技术

背景情况:

  • 与生物材料相关的感染带来了重大的临床挑战,特别是随着抗生素耐药性增加.
  • 银正在成为骨感染的强效抗菌剂,提供快速作用和降低耐药性.
  • 然而,银的固有细胞毒性会阻碍组织再生,使其在植入物中的使用复杂化.

研究的目的:

  • 审查银在生物材料中的应用,以对抗感染.
  • 为了应对最大限度地提高银的抗菌效果,同时最大限度地降低耐药性的挑战.
  • 探索将银与生物材料结合的方法,并指导硬组织植入物的未来研究.

主要方法:

  • 文献综述侧重于含银的生物材料.
  • 分析银对生物材料物理化学,结构和生物特性的影响.
  • 讨论银在生物材料中的挑战和未来方向.

主要成果:

  • 银表现出高的抗菌及时性和效率,具有较低的抗性潜力.
  • 银的细胞毒性会导致炎症和氧化应激,阻碍组织再生.
  • 合适的银结合方法对于平衡抗菌和生物相容性质至关重要.

结论:

  • 含有银的生物材料为植入物相关感染提供了抗生素的有希望的替代品.
  • 需要进一步的研究来优化银的整合方法和减轻细胞毒性.
  • 解决商业化和深入研究的挑战是临床翻译的关键.