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Updated: Jul 27, 2025

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在人类iPSC衍生的神经网络中测定化学长期潜能

Deborah Pré1, Alexander T Wooten1, Haowen Zhou1

  • 1Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.

Methods in molecular biology (Clifton, N.J.)
|June 10, 2023
PubMed
概括

研究人员开发了一种新方法,可以在从干细胞中获得的人类神经元中化学诱导长期强化 (LTP). 这种技术可以研究神经元可塑性和神经疾病模型中的分子变化.

关键词:
人类诱导的多能干细胞衍生的神经元.长期增强潜力 长期增强潜力多电极阵列多电极阵列.突触性可塑性 突触性可塑性

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Long-term Potentiation01:35

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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