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儿童心脏秋亚型:它是否会影响对治疗的反应?
Anshu Srivastava1, Ujjal Poddar2, Amrita Mathias2
1Department of Pediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226 014, India. avanianshu@yahoo.com.
概括
儿科阿喀拉西亚亚型,I型和II型,表现出类似的临床特征和对气动扩张 (PD) 的治疗反应. 二型表现出比I型更高的下消化管关节压力和较少扩张的食道.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 食道运动障碍 食道运动障碍
- 亚哈拉西亚亚型的分类
背景情况:
- 阿哈拉西亚亚型会影响成年人的治疗结果,但对儿童的数据有限.
- 了解儿科阿喀拉西亚的这些差异对于量身定制的治疗方法至关重要.
研究的目的:
- 调查儿童中阿喀拉西亚亚型之间的临床-实验室区别.
- 为了比较儿科患者在阿喀拉西亚亚型之间的治疗应答率.
主要方法:
- 48名被诊断患有阿喀拉西亚的儿童接受了临床评估,吞,高分辨率计量 (HRM) 和胃镜检查.
- 使用芝加哥分类基于HRM发现的Achalasia亚型被分类.
- 主要治疗包括气动扩张 (PD) 或手术,成功率以Eckhardt分数≤3.3来定义.
主要成果:
- 甲拉西亚 I 型 (n=19) 和 II 型 (n=19) 呈现出类似的临床症状,主要是缺食和反.
- 与I型相比,II型阴症在定时食管图 (TBE) 上显示出明显更高的基底下食管缩器 (LES) 压力和较少扩张的食道,与I型相比.
- 最初的PD表现出类型I和类型II的相似成功率 (86.6%与92.8%),PD后肌肉切除的需要没有显著差异.
结论:
- 类型I和II的儿科阿喀拉西亚具有相似的临床表现,并且对最初的气动扩张有同样好的反应.
- 第二种类型的形症的特点是 LES 压力较高,食道扩张较小,而不是I型.
- 定时食管图 (TBE) 是评估气动扩张后治疗反应的宝贵工具.
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