产前母亲的压力与母亲和新生儿DNA甲基化中的特定地点和年龄加速变化有关
Edward B Quinn1,2, Chu J Hsiao1,2,3, Felicien M Maisha1,2,4,5
1Department of Anthropology, University of Florida, Gainesville, FL, USA.
Epigenetics
|June 10, 2023
概括
母亲的压力通过DNA甲基化变化影响儿童的健康. 创伤,特别是性和与战争有关的创伤,会改变母亲和新生儿的DNA甲基化和表观遗传年龄,影响出生体重.
科学领域:
- 环境表观遗传学环境表观遗传学
- 健康和疾病的发育起源.
背景情况:
- 产前母亲的压力会对孩子的健康产生负面影响.
- 关联母亲压力与儿童健康结果的机制尚不清楚.
- 表观遗传变异,如DNA甲基化,对环境因素敏感,并调节基因表达.
研究的目的:
- 研究母亲压力对母亲和新生儿的DNA甲基化的影响.
- 探索不同类型的孕产妇压力 (一般创伤,性创伤,战争创伤,慢性压力) 与表观遗传变化之间的关联.
- 确定DNA甲基化变化是否预测新生儿健康结果.
主要方法:
- 在刚果民主共和国招募了155名母亲新生儿二合一.
- 评估母亲的压力使用四个措施:一般创伤,性创伤,战争创伤和慢性压力.
- 分析了母亲和新生儿的DNA甲基化模式和表观遗传年龄加速.
主要成果:
- 在母亲和新生儿中确定了与一般性,性和战争创伤相关的差异甲基化位置 (DMP),但不是慢性压力.
- 性创伤与母亲的表观遗传衰老加速相关.
- 一般和战争创伤与新生儿表观遗传年龄加速相关.
- 在新生儿中,与母亲压力相关的DMPs被丰富为胚胎和胎儿细胞类型的调节元素.
- 与新生儿战争创伤相关的DMP预测了新生儿的出生体重.
结论:
- 孕产妇的压力与特定地点的DNA甲基化变化和母婴和新生儿的表观遗传年龄加速有关.
- 这些表观遗传变化可能会影响产前压力对儿童健康的影响.
- 新生儿的战争创伤相关的表观遗传变化可能会影响出生结果.
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