在法医精神病患者中对抗精神病多药物的全国性研究
Stine Lassen1,2, Thale Heintz1,2, Tilde Pedersen1,2
1Department of Forensic Psychiatry, Aarhus University Hospital Psychiatry, Aarhus, Denmark.
International journal of circumpolar health
|June 10, 2023
概括
抗精神病药物多药 (APP),即使用两种或两种以上的抗精神病药物,在格陵兰的法医精神病患者中占35%. 这种做法与特定的抗精神病药物有关,突出了改善治疗策略的需要.
科学领域:
- 法医精神病学 法医精神病学
- 心理药理学 心理药理学
- 心理健康服务研究研究 心理健康服务研究
背景情况:
- 抗精神病多药 (APP) 是一种常见的做法,用于管理严重的精神疾病,尽管指南建议反对它.
- 法医精神病患者经常出现复杂的并发症,包括严重的精神疾病和物质使用障碍,增加治疗挑战.
- 了解这种脆弱人群中APP的患病率和相关因素对于优化心理药物干预至关重要.
研究的目的:
- 确定在格陵兰的法医精神病患者中抗精神病多种药物 (APP) 的流行率.
- 确定与这种患者群体中APP实践相关的人口统计,法医和临床因素.
- 为改进法医精神病学中心理药物治疗的未来战略提供信息.
主要方法:
- 在全国范围内进行了一项回顾性横截面研究,使用来自电子患者档案,法庭文件和法医精神病学评估的数据.
- 研究人口包括74名被诊断患有精神分裂症或其他ICD-10 F2疾病的法医精神病患者.
- 统计分析包括未配对的t测试和奇平方或费舍尔的精确测试来评估关联.
主要成果:
- 抗精神病多种药物 (APP) 的患病率为35% (74名患者中有26名).
- APP与克洛扎宾,奥兰扎宾,阿里皮普拉和第一代抗精神病药物 (FGA) 的处方有显著的关联.
- 没有人口或法医因素被明确地详细描述为在抽象中显著相关,但临床复杂性是暗示的.
结论:
- 抗精神病多药 (APP) 是格陵兰法医精神病患者的常见治疗策略,尽管存在指导方针.
- 特定抗精神病药物的使用,包括克洛扎宾,奥兰扎宾,阿里皮普拉和FGA,与APP有关.
- 对APP的进一步研究对于增强具有复杂心理健康需求的法医精神病患者的精神药理学护理至关重要.
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