奇托寡合物的分子量与相应的粘度和抗菌活性的相关性
Junqing Qian1, Xi Wang1, Yan Chen1
1College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, 310014, China.
Carbohydrate research
|June 10, 2023
概括
具有粘度平均分子量 (Mv) 在52.5-145.0 kDa之间的奇托寡合物表现出强烈的杀菌作用. 这种分子量范围显示了抗菌药物对抗细菌和真菌的潜在应用.
科学领域:
- 聚合物化学 聚合物化学
- 微生物学 微生物学
- 生物材料科学 生物材料科学
背景情况:
- 奇托是一种天然的多糖,具有由其分子量影响的抗菌性质.
- 了解酸盐寡合体分子量及其有效性之间的关系对于开发向抗菌剂至关重要.
研究的目的:
- 研究酸溶液中奇托寡合物的粘度与它们的粘度平均分子量 (Mv) 之间的相关性.
- 为了确定表现出显著杀菌活性的奇托寡合体的特定Mv范围.
- 为了确定基托寡合物的抗菌作用的最佳条件.
主要方法:
- 使用稀释酸降解基托以产生基托寡合物.
- 使用FT-IR,XRD,1H NMR和13C NMR进行分子结构的特征.
- 对大肠杆菌,黄金杆菌和白杆菌的杀菌活性使用板计数方法进行评估,杀菌率作为关键指标.
主要成果:
- 奇托寡合物的分子结构与原始的奇托相似.
- 在乙酸溶液中的奇托寡合物的粘度与它们的Mv之间观察到正相关性.
- 基托寡合体的Mv为52.5145.0kDa,显示出强大的杀菌性能.
结论:
- 基托寡合体的Mv范围在52.5至145.0kDa之间,具有显著的抗菌潜力.
- 杀菌活性的最佳条件包括细菌度为0.5g/L,真菌度为1.0g/L,pH值为6.0持续30分钟.
- 这些发现凸显了特定分子量奇多寡合体在抗菌素配方中的潜在应用.
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