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Updated: Aug 4, 2026

Quantification of Proteins Using Peptide Immunoaffinity Enrichment Coupled with Mass Spectrometry
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Quantification of Proteins Using Peptide Immunoaffinity Enrichment Coupled with Mass Spectrometry

Published on: July 31, 2011

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通过微芯片毛细体电泳-质谱法探索IgG2单克隆抗体潘蒂图穆马布的蛋白形状

Florian Füssl1, Sara Carillo1, Silvia Millán-Martín1

  • 1National Institute for Bioprocessing Research & Training, Fosters Avenue, Mount Merrion, Blackrock, A94 X099 Co. Dublin, Ireland.

Journal of pharmaceutical and biomedical analysis
|June 10, 2023
PubMed
概括

帕尼图穆马布的分析揭示了由于N-终端质酸盐的形成而导致的未识别的形式. 先进的毛细管电泳质谱法 (CE-MS) 确定了42种异构体,突出了生物制药快速识别测试的局限性.

关键词:
毛细电泳 - 质谱学 - 毛细电泳在 N-终端的质甲酸盐.原生质谱学原生质谱学.帕尼图穆马布 (Panitumumab) 是一个后翻译修改后的修改.

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Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...