年龄是否会影响乳腺癌的结果?
Emily B Jackson1, Lovedeep Gondara2, Caroline Speers2
1BC Cancer Vancouver Centre, Vancouver, BC, Canada; University of British Columbia, Canada.
Breast (Edinburgh, Scotland)
|June 10, 2023
概括
被诊断为乳腺癌的非常年轻和老年患者都面临着更差的预后. 这项研究强调诊断时的年龄是影响乳腺癌生存结果的重要危险因素.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 关于乳腺癌诊断时年龄对患者结果的影响,存在相互矛盾的数据.
- 了解与年龄相关的差异对于个性化治疗策略至关重要.
研究的目的:
- 调查诊断时年龄对乳腺癌特定存活率 (BCSS) 和整体存活率 (OS) 的影响.
- 在不同年龄组中识别不同的临床病理和治疗模式.
主要方法:
- 这是一项基于人口的回顾性研究,对24469名在2005年至2014年期间被诊断为侵袭性乳腺癌的患者进行了回顾性研究.
- 跨年龄组的临床,病理和治疗变量的分析:<35,35-39,40-49,50-59,60-69,70-79和≥80.
- 评估年龄对BCSS和OS的影响,控制亚型,淋巴血管侵入 (LVI),阶段和治疗.
主要成果:
- 年轻的患者 (<35,35-39岁) 经常呈现高风险特征 (HER2+,三阴性,晚期) 并接受更积极的治疗.
- 老年患者 (≥80) 更有可能患有激素敏感,HER2阴性,较低阶段的疾病,并且接受的治疗不那么密集.
- 诊断时的两种极端年龄被确定为预后较差的独立风险因素.
结论:
- 诊断时的年龄是乳腺癌的一个关键的,独立的预后因素.
- 在极端的年龄阶段存在明显的临床和治疗差异.
- 这些发现可以帮助临床医生改进结果预测,并根据证据定制基于证据的治疗建议.
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