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对于RNA-蛋白相互作用的结构建模存在挑战

Xudong Liu1, Yingtian Duan1, Xu Hong1

  • 1School of Physics, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, China.

Current opinion in structural biology
|June 10, 2023
PubMed
概括

深度学习和共同进化方法的最新进展正在改善RNA结合蛋白 (RBP) 相互作用的建模. 将蛋白质数据库 (PDB) 和CLIP数据与深度学习相结合,为蛋白质-RNA复杂结构预测提供了一种可靠的方法.

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RNA Structure

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Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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Nucleic Acid Structure

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RNA Stability

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