双相情感障碍中体白质物质的修饰:一个DTI通道图的审查
Giovanni Videtta1, Letizia Squarcina2, Maria Gloria Rossetti3
1Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.
Journal of affective disorders
|June 10, 2023
概括
扩散张力成像揭示了双相情感障碍患者体的结构变化. 这些白质变化可能解释执行处理,运动控制和视觉记忆中的认知障碍.
科学领域:
- 神经成像是一种神经成像.
- 精神疾病 精神疾病
- 白物质的解剖学 白物质的解剖学
背景情况:
- 扩散张力成像 (DTI) 曲谱越来越多地用于研究精神疾病中的白质 (WM) 变化.
- 体 (CC) 在与双相情感障碍 (BD) 相关的病理生理学和认知缺陷中发挥着重要作用.
研究的目的:
- 审查使用DTI通道图的BD患者中CC神经解剖学变化的最新发现.
主要方法:
- 在PubMed,Scopus和Web of Science数据库上进行了系统的文献搜索,直到2022年3月.
- 分析了符合纳入标准的10项研究.
主要成果:
- 研究始终表明,在BD患者中,CC的基因,体和脏中的小分异性减少.
- 研究结果还表明,CC中纤维密度降低,通道长度改变,辐射和平均扩散率增加.
结论:
- 在BD患者中存在CC的结构性修改.
- 这些CC变化可能是执行处理,运动控制和视觉记忆中的认知障碍的基础.
- 脑变化表明CC连接的大脑区域内的功能信息传输和形态影响受损.
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