青少年患有双相情感障碍的形态异常及其与临床特征的关系
Wenbin Li1, Du Lei2, Maxwell J Tallman3
1Departments of Radiology, Huaxi MR Research Center (HMRRC), West China Hospital of Sichuan University, Chengdu 610000, Sichuan, PR China; Department of Psychiatry and Behavioral Neuroscience, Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA; Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, PR China.
Journal of affective disorders
|June 10, 2023
概括
患有双相情感障碍 (BD) 的青少年在处理情绪至关重要的大脑区域中表现出显著的神经结构缺陷. 诸如ADHD或精神病等并发症可能会使这些解剖学变化变得更糟.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 双极性障碍 (BD) 是一种严重的精神健康状况,影响年轻人.
- 了解儿科BD的神经解剖学基础对于早期干预至关重要.
- 以前的研究表明,BD的成年人有结构性大脑异常,但对年轻人的数据不那么有说服力.
研究的目的:
- 为了描述患有第一期双相情感障碍的青少年的神经解剖学.
- 在这个人群中研究神经结构缺陷与临床特征之间的相关性.
主要方法:
- 结构性MRI扫描 (4T) 采集了105名没有药物治疗的青少年和61名健康对照.
- 使用Freesurfer V6.0.0.进行皮质厚度和皮质下灰质体积的分析.
- 线性模型评估了神经解剖学和临床/人口因素之间的关系.
主要成果:
- 与对照人群相比,患有BD的青少年在额头,头和前 cingulate 区域的皮质厚度减少.
- 在6个下皮层区域观察到灰质体积的减少,包括质体,质体,杏仁体和尾状体.
- 并发性注意力缺陷多动性障碍 (ADHD) 或精神病症状与更严重的皮下灰质缺乏相关.
结论:
- 患有BD的年轻人表现出皮质和皮质下区域的显著神经结构缺陷,这些区域参与了情绪处理和调节.
- 临床变异性和并发症似乎影响了这些解剖学变化的严重程度.
- 这些发现凸显了神经成像在理解儿科BD及其异质性方面的重要性.
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