慢性查加斯病患者的氧化应激评估
Francilene Capel Tavares de Carvalho1, Larissa Ragozo Cardoso de Oliveira1, Mariana Gatto1
1Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
Parasitology international
|June 10, 2023
概括
患有夏加斯病症状的患者表现出更高的氧化应激,由增加的DNA损伤和氧化 (NO) 水平,以及降低的抗氧化能力和维生素E,这突出了症状和无症状个体之间的显著差异.
科学领域:
- * 寄生虫学和热带医学
- * 分子生物学和生物化学
背景情况:
- *由Trypanosoma cruzi引起的查加斯病 (CD) 是一个全球性的健康问题.
- *免疫反应涉及炎症,活性氧物种 (ROS) 和氧化 (NO),可能导致DNA损伤.
- *一种内源性抗氧化剂系统可以抵消氧化应激.
研究的目的:
- * 在查加斯病患者中评估氧化应激标志物.
- * 为了比较症状和无症状个体之间的这些标志物.
主要方法:
- *研究包括三个组:无症状CD (n=8),症状CD (n=14) 和健康对照组 (n=20).
- *分析的参数包括DNA损伤,血清氧化 (NO) 水平,亲水抗氧化能力 (HAC) 和维生素E水平.
主要成果:
- * 症状CD患者的DNA损伤和NO水平升高.
- *在有症状的患者中观察到水友性抗氧化能力 (HAC) 和维生素E的降低.
- *与无症状患者和对照人群相比,这些标志物有显著差异.
结论:
- *有症状的查加斯病患者经历了较高的氧化应激.
- * 这种情况的特点是DNA损伤增加和NO的产生.
- * 降低抗氧化能力和维生素E水平与临床症状有关.
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