通过抗癌甲基腺酸酸化酶过渡状态抑制剂的酸和氧化还原失调

Timothy Salita1, Yepy H Rustam2, Vinzenz Hofferek3

  • 1School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand; Department of Biochemistry and Pharmacology, University of Melbourne, Parkville, Australia.

概括

甲基-DADMe-immucillin-A (MTDIA) 抑制了5'-甲基腺酸酶 (MTAP),影响了癌细胞脂质组. 这项研究揭示了MTDIA改变了脂质信号和免疫反应,这表明了新的治疗机制.

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