人类遗传学影响了微生物组的组成,尽管吸入性皮质类固醇治疗,但也与喘恶化有关
Javier Perez-Garcia1, Antonio Espuela-Ortiz1, José M Hernández-Pérez2
1Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna (ULL), La Laguna, Tenerife, Spain.
The Journal of allergy and clinical immunology
|June 10, 2023
概括
人类遗传学在喘恶化中影响上呼吸道微生物群. 这项研究确定了与喘并发症相关的基因和潜在的治疗点,如核因子-κB和葡萄糖皮质类固醇受体.
科学领域:
- 基因组学和微生物学
- 免疫学和呼吸系统医学
背景情况:
- 上呼吸道微生物组在喘恶化中发挥着作用,即使在吸入性皮质类固醇 (ICS) 治疗中也是如此.
- 这种微生物群对喘相关细菌的影响的遗传调节尚未得到充分理解.
研究的目的:
- 确定调节与喘恶化相关的呼吸道微生物组特征的基因和生物通路.
- 研究喘患者对ICS治疗反应的遗传影响.
主要方法:
- 全基因组关联研究 (GWAS) 在欧洲喘患者的唾液,鼻和喉样本上进行 (n=257).
- 与恶化相关的微生物组特征相关的遗传变异被分析为生物途径中的丰富.
- 显著的发现被复制在不同的儿科群体中,并与已知的ICS反应单核酸多态 (SNP) 相比进行评估.
主要成果:
- 与恶化相关的微生物组特征相关的基因在喘并发症 (如肥胖和吸烟) 的途径中得到了丰富.
- 通过三静素A,核因子-κB,葡萄糖皮质类固醇受体和CCAAT/增强剂结合蛋白转录因子的调节被确定.
- 发现特定的SNP (rs5995653,rs6467778,rs5752429) 是上呼吸道细菌的微生物群定量特征位点,例如Streptococcus和Campylobacter.
结论:
- 与喘恶化的微生物组特征相关的基因可能会影响并发症.
- 这项研究强调了向喘恶化途径的治疗潜力,这些途径涉及三素A,核因子-kB,葡萄糖皮质类固醇受体和CCAAT/增强剂结合蛋白.
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