在中国普通成年人群的血清中,多甲的度和时间趋势以及多甲对甲状腺功能的影响
Dan Chen1, Xinyu Lou1, Junsong Bao2
1College of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, China.
Environmental research
|June 10, 2023
概括
人类血清仍然含有多甲 (PCN),随着时间的推移,一些度会增加. 这些持久性有机污染物可能会通过干扰甲状腺激素功能而构成风险,特别是对女性来说.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 人类健康 人类健康 人类健康
背景情况:
- 多甲 (PCN) 是持久性有机污染物,目前没有生产或使用.
- 在全球范围内,PCN在人体血清中继续被检测到,因此需要了解暴露趋势.
研究的目的:
- 调查人类血清中多甲 (PCN) 度的时间趋势.
- 评估潜在的性别特异性风险和PCN毒性的机制.
主要方法:
- 在连续五年 (2012-2016) 分析了32名成人的血清样本以检测PCN度.
- 采用分子对接技术,研究特定PCN原原体与甲状腺激素通路的相互作用.
主要成果:
- 在研究期间,在人血清中没有观察到总PCN度的显著下降.
- 随着时间的推移,某些PCN类原体 (如CN20) 的度增加.
- 与男性血清相比,女性血清中发现的CN75度显著更高.
- 发现CN75干扰甲状腺激素运输,CN20干扰甲状腺激素受体结合,这表明有协同效应.
结论:
- 人类对PCN的暴露仍在持续,一些同源呈现越来越大的趋势.
- PCN,特别是CN75和CN20,对甲状腺激素调节有潜在的风险,对女性的影响更大.
- 这些发现强调了与遗留污染物相关的持续风险及其对内分泌功能的影响.
相关概念视频
Types of Toxins
1.8K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.8K
Functions of Thyroid Hormones
2.9K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.9K
Synthesis and Regulation of Thyroid Hormones
4.8K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.8K


