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双甲降低了由聚烯纳米塑料引起的发育性毒性和组织病理变化,在发育中的海洋医学中,比如Oryzias melastigma

Fuwei Yu¹, Fei Jin², Yi Cong²

¹School of Chemical Engineering, Dalian University of Technology, Dalian, 116024, China; Key Laboratory for Ecological Environment in Coastal Areas (Ministry of Ecology and Environment), Marine Debris and Microplastic Research Center, Department of Marine Chemistry, National Marine Environmental Monitoring Center, Dalian, 116023, China.

|June 10, 2023

概括

双A (BPA) 暴露减少了聚乙烯纳米塑料 (PS-NP) 在海洋中鱼类的发育毒性. BPA减轻了形和肝炎等负面影响,这表明相互作用减少了PS-NP生物积累.

科学领域:

环境毒理学环境毒理学
海洋生物学海洋生物学
生态毒理学生态毒理学

背景情况:

纳米塑料 (NP) 是普遍存在的海洋污染物,具有未知的共同暴露效应.
双A (BPA) 是一种常见的内分泌干扰化学物质,在海洋环境中发现.
了解污染物对海洋生物的综合影响对于风险评估至关重要.

研究的目的:

为了研究共暴露的聚乙烯纳米塑料 (PS-NPs) 和BPA在海洋medaka (Oryzias melastigma) 的发育毒性.
为了确定BPA是否会在环境相关度下影响PS-NP的毒性.
阐明观察到的毒性相互作用背后的潜在机制.

主要方法:

海洋medaka胚胎暴露在PS-NPs,BPA或它们的组合中.
评估了发育终点,包括心率,存活率,身体长度和幼虫形.
检查肝脏组织的组织病理变化,以评估炎症反应.

主要成果:

单独的PS-NPs导致心率下降,幼虫长度减少,存活率降低,以及诱导变形 (出血,面异常).
同时暴露于BPA显著减轻了PS-NP引起的所有不良发育影响.
PS-NP增加了肝脏组织病理学得分和炎症;与BPA同时暴露防止了这些变化.

结论:

BPA减轻了海洋中PS-NP的发育毒性,可能是通过减少PS-NP的生物积累.
这种相互作用凸显了化学混合物在海洋生态系统中的复杂影响.
需要使用奥米克方法进行进一步的研究,以了解纳米塑料和化学污染物联合毒性的机制.

关键词:

双 A 是一种双.共同暴露共同暴露胚胎是如何形成的幼虫的幼虫可以海洋鱼类是一种海洋鱼类.聚乙烯是一种聚乙烯.

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Teratogenicity

Teratogenicity

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