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在前列腺癌中,致癌蛋白激酶/ATPase RIOK1通过c-myc/E2F转录因子轴进行上调

Florian Handle1, Martin Puhr2, Martina Gruber2

  • 1Department of Urology, Medical University of Innsbruck, Innsbruck, Austria; Institute of Pathology, Neuropathology and Molecular Pathology, Medical University of Innsbruck, Innsbruck, Austria.

The American journal of pathology
|June 10, 2023
PubMed
概括

蛋白激酶RIOK1在前列腺癌 (PCa) 中过度表达,并驱动癌细胞的增殖. 用托约卡米辛抑制RIOK1显示出显著的抗癌作用,这表明RIOK1是PCa治疗的潜在治疗标.

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