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局部免疫调节技术使细胞和器官移植成为可能

Amanda Nash¹, Nienke Lokhorst², Omid Veiseh¹

¹Department of Bioengineering, Rice University, Houston, TX 77030, USA.

Trends in molecular medicine

|June 10, 2023

概括

局部免疫调节正在彻底改变细胞和器官移植. 工程解决方案,包括基因组编辑和生物材料,增强癌症和自身免疫性疾病等疾病的治疗方法.

科学领域:

生物技术是生物技术.
免疫学免疫学免疫学
移植科学移植科学

背景情况:

基于细胞的免疫调节疗法在治疗癌症和自身免疫性疾病方面取得了临床成功.
局部免疫调节是一种新兴的模式,具有细胞和器官移植的变革潜力.

研究的目的:

审查局部免疫调节技术的最新工程进展.
专注于细胞和器官移植中的应用.

主要方法:

在细胞移植 (干细胞,CAR-T细胞,小岛) 中临床成功的审查.
详细检查使用基因组编辑和生物材料进行局部免疫调节的临床前研究.

主要成果:

突出基于细胞的疗法的成功临床应用.
展示基因组编辑和生物材料开发的进步,以加强免疫调节.
确定改善长期免疫调节的关键策略.

结论:

局部免疫调节技术即将彻底改变移植.
工程解决方案为增强细胞和器官移植成功提供了巨大的潜力.
未来的机遇在于完善这些方法,以便在临床和商业上广泛采用.

关键词:

生物材料是一种生物材料.细胞移植移植细胞移植临床翻译临床翻译局部免疫调节局部免疫调节干细胞是干细胞的组成部分.

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