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相关概念视频

Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
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Clinical Applications of Epidermal Stem Cells01:19

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Phases of Wound Repair

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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
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Renewal of Skin Epidermal Stem Cells01:12

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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相关实验视频

Updated: Jul 27, 2025

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
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无痕的伤口愈合被核心外微针编程.

Ying Zhang1, Shenqiang Wang2, Yinxian Yang1

  • 1Key Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, China.

Nature communications
|June 10, 2023
PubMed
概括

这项研究引入了一种新的微针贴片,可以动态调整伤口愈合. 编程微针 (PF-MNs) 抗击细菌,减少炎症,防止痕,改善组织修复.

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科学领域:

  • 生物材料科学 生物材料科学
  • 再生医学是一种再生医学.
  • 伤口治愈研究研究 伤口治愈研究

背景情况:

  • 慢性伤口愈合是复杂的,通常由于药物输送挑战和不适当的时间而失败.
  • 现有的治疗方法很难有效地解决愈合伤口的动态微环境.

研究的目的:

  • 开发可编程的微针阵列补丁 (PF-MNs),用于动态调制伤口免疫微环境.
  • 解决在不同的伤口愈合阶段药物递送效率和治疗时间的局限性.

主要方法:

  • 设计了一个具有编程函数 (PF-MN) 的核心微针阵列补丁.
  • 利用激光诱导的活性氧物种 (ROS) 用于早期细菌生物膜破坏.
  • 包含一个对ROS敏感的外,用于控制抗炎和抗痕剂 (脊椎素) 的释放.

主要成果:

  • 通过ROS生成,PF-MN证明有效地对抗多药耐药细菌生物膜.
  • 微针芯成功中和了炎症因素,促进了从炎症过渡到扩散的过程.
  • 维特波芬释放通过阻断纤维细胞中的Engrailed-1 (En1) 激活来抑制痕形成.
  • 在急性和慢性小鼠伤口模型中,PF-MN促进了无痕的修复,并在子耳朵中减少了缩性痕.

结论:

  • 开发的PF-MN为动态,阶段特定的伤口管理提供了有前途的战略.
  • 这项技术有效地解决了细菌感染,炎症和痕形成在伤口愈合.
  • PF-MN代表了再生医学的重大进步,改善了伤口修复结果.