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在儿童癌症治疗后异常的HDL脂质和蛋白质组成:一个关联性研究

Véronique Bélanger^1,2, Sophia Morel^1,2, Mélanie Napartuk^1,2

¹Research Centre, CHU Sainte-Justine, 3175 Chem. de la Côte-Sainte-Catherine, Montreal, QC, H3T 1C5, Canada.

Lipids in health and disease

|June 10, 2023

概括

儿童癌症幸存者通常具有低高密度脂蛋白胆固醇 (HDL-C). 德克索鲁比暴露和肥胖影响治疗后早期的HDL组成,增加脂质失调风险.

科学领域:

儿科瘤学儿科瘤学
心血管健康心血管健康
脂质代谢脂质代谢是什么

背景情况:

长期儿童癌症幸存者 (CCS) 面临高血脂不良的风险,特别是低高密度脂蛋白胆固醇 (HDL-C).
在CCS中,对低HDL-C的患病率和治疗在治疗完成后不久对HDL组成的影响的了解有限.

研究的目的:

为了调查儿童和青少年癌症治疗后的低HDL-C的患病率.
评估特定的癌症疗法,特别是多克索鲁比辛对高密度胆固醇组成和脂质水平的影响.
为了确定与这种人群中脱脂症相关的临床因素.

主要方法:

一项关联性研究分析了50名儿童和青少年在完成癌症治疗后4年内.
评估了临床特征,空腹血脂,阿波利波蛋白 (Apo A-I) 和高密度胆固醇 (HDL2,HDL3) 分数的组成.
后勤回归评估了低HDL-C的关联;在一个子组中,HDL组成与健康对照进行了比较.

主要成果:

16%的患者表现出较低的HDL-C,主要是诊断时的青少年.
较高的多克索鲁比辛剂量与降低的HDL-C和Apo A-I水平相关.
观察到异常的高密度胆固醇成分 (甘油三升高,降低雌性胆固醇),与多克索鲁比暴露和超重/肥胖有关.

结论:

早期的儿科癌症治疗后,HDL-C,Apo A-I和HDL组成的异常显而易见.
年龄,超重/肥胖和多克索鲁比暴露显著影响这些脂质异常.

关键词:

青少年青少年青少年它们是阿波利波蛋白.化疗剂化疗剂化疗剂孩子孩子孩子孩子胆固醇胆固醇胆固醇临床研究临床研究脱脂血症是一种失脂血症.高密度脂蛋白是一种高密度脂蛋白.脂蛋白质是一种脂蛋白质.肥胖问题肥胖问题

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