皮肤从出生到10岁的成熟:结构,功能,组成和微生物群
Georgios N Stamatas1, Pierre-Francois Roux1, Elise Boireau-Adamezyk1
1Translational Science, Johnson & Johnson Santé Beauté France, Issy-les-Moulineaux, France.
儿童时代的皮肤屏障功能在6岁时成熟,达到成人水平. 皮肤组成和微生物群也在整个童年发展,根据身体部位而异.
科学领域:
- 皮肤病学 皮肤病学
- 儿科生理学 儿科生理学
- 微生物组研究 微生物组研究
背景情况:
- 婴儿和成人皮肤生理学表现出显著的差异.
- 关于老年儿童皮肤成熟的数据有限.
- 了解儿童皮肤发育对于儿科护理至关重要.
研究的目的:
- 研究儿童健康皮肤的成熟过程.
- 为了比较不同儿科年龄组和成年人的皮肤参数.
- 分析儿童时期皮肤生理学和微生物群的特定位置变化.
主要方法:
- 在四个年龄组招募了80名参与者:婴儿 (0-2岁),幼儿 (3-6岁),老年儿童 (7-9岁) 和成年人 (25-40岁).
- 记录了关键的皮肤参数,包括皮肤间的水分流失 (TEWL),脂质紧度,角层 (SC) 厚度,角细胞大小,乳酸,总氨基酸,水分和黑色素水平.
- 对每个年龄组的背部前臂皮肤微生物组的组成进行了分析.
主要成果:
- 皮肤屏障功能,包括TEWL,脂质紧性,SC厚度和角质细胞大小,在大约6岁时成熟到成人水平.
- 婴儿和幼儿在SC中表现出较高的乳酸和较低的总氨基酸,表明细胞周转速度更快.
- 在所有年龄段,TEWL和皮肤水分在脸上始终高于手臂.
- 皮肤颜色会随着年龄的增长而增加,因为黑色素水平较高.
- 皮肤微生物群在儿童和成年人之间存在显著差异,在儿童中占主导地位的Firmicutes,在成年人中占主导地位的Proteobacteria.
结论:
- 健康的皮肤生理和微生物组在整个幼儿时期以特定地点的方式成熟.
- 皮肤屏障功能的关键指标在6岁时达到成人水平.
- 对于童年期间的皮肤生理学和微生物组合,存在不同的发育轨迹.
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