后部皮层缩和逻辑开放的渐进性失言症的扩散性变化:一个纵向扩散张力图像研究.
Neha Atulkumar Singh1, Jonathan Graff-Radford1, Mary M Machulda2
1Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Journal of Alzheimer's disease : JAD
|June 11, 2023
概括
后皮层缩 (PCA) 和逻辑开放性渐进性失言症 (LPA) 呈现白质变性. 扩散张力成像 (DTI) 可以识别这些条件的特定生物标志物,帮助诊断.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 生物标志物 生物标志物
背景情况:
- 后皮层缩 (PCA) 和逻辑开放性渐进性失言症 (LPA) 涉及不同的神经退行性模式.
- 在PCA和LPA中,纵向白质管道退化仍未得到充分研究.
研究的目的:
- 调查PCA和LPA中纵向白质变性.
- 为了确定PCA和LPA的表型特定的横截面和纵向扩散张力成像 (DTI) 生物标志物.
主要方法:
- 招募了25名PCA,22名LPA和25名认知正常 (CU) 个体.
- 使用结构性MRI与DTI,包括一年的随访.
- 应用混合效应模型和接收器运行特征 (ROC) 分析来评估DTI指标.
主要成果:
- PCA和LPA在头部,部和部区域显示重叠的白质变性.
- PCA表现出尾和尾白质的退化;LPA表现出尾和下尾白质的退化.
- 最好的区别是PCA与LPA的下白质完整性 (AUROC=0.82).
结论:
- 这些发现增强了对PCA和LPA白质退化的理解.
- 扩散张力成像 (DTI) 显示为这些条件的诊断生物标志物具有前途.
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