研究俄罗斯医生对结核病药物遗传学的看法
B I Kantemirova1, E M Bogorodskaya2, M S Poptsova3
1Federal State Budgetary Educational Institution of Higher Education, Astrakhan State Medical University, Bakinskaya, Russia.
The International journal of risk & safety in medicine
|June 11, 2023
概括
药物遗传学测试 (PGx) 被俄罗斯植物学家认为很重要,但人们的认识很低,缺乏指导方针阻碍了其使用. 增加PGx的实施可以提高结核病治疗的安全性和结果.
科学领域:
- 药理学 药理学是指药理学的学科.
- 遗传学 遗传学是一种遗传学.
- 医学科学 医学科学 医学科学
背景情况:
- 药物遗传学测试 (PGx) 并未在植物学实践中得到广泛应用.
- 在目前的结核病治疗方案中对PGx方法的认识和整合有限.
研究的目的:
- 评估俄罗斯植物学家,住院生和研究生在利用PGx.x.方面的认识和准备程度.
- 确定PGx实施的障碍,以提高治疗安全性,预测药物不良反应 (ADR) 和个性化抗结核治疗.
主要方法:
- 在314名植物生理学家和185名来自俄罗斯医学院继续专业教育 (RMACPE) 的住院生/研究生中进行了调查.
- 该调查在Testograf.ru上进行,包括25个医生问题和22个实习生问题,评估PGx知识和应用准备.
主要成果:
- 超过50%的受访者准备使用PGx,这表明他们意识到其潜在的好处.
- 确定的主要障碍包括临床指南中没有PGx (超过50%),缺乏大规模试验 (超过37%) 和医生知识不足 (超过41%).
- 参与者对pharmgkb.org资源的认识特别低.
结论:
- 大多数植物学家和实习生承认PGx的重要性,并表示愿意采用它.
- 对PGx能力和资源的认识较低,加上系统性障碍,阻碍了其在俄罗斯的临床整合.
- 实施PGx服务具有显著的潜力,可以提高患者的服从性,减少不良反应,提高抗结核治疗的质量.
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