软纸厂工人的癌症发病率:一个队列研究
Kjell Torén1,2, Richard L Neitzel3, Helena P Eriksson2
1School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, Occupational and Environmental Medicine, University of Gothenburg, Gothenburg, Sweden.
American journal of industrial medicine
|June 11, 2023
概括
职业接触软纸尘与瑞典造纸厂工人中结肠,小肠和肺癌的发病率较高有关. 该研究还指出,瘤和多叶膜间皮瘤的风险增加,尽管原因尚不清楚.
科学领域:
- 职业健康 职业健康 职业健康 职业健康
- 流行病学 流行病学
- 环境健康 环境健康
背景情况:
- 软纸厂的工人可能面临职业暴露于尘埃.
- 长时间暴露于软纸尘的健康影响尚未完全理解.
- 之前的研究并没有明确地将纸尘暴露与特定癌症类型联系起来.
研究的目的:
- 调查职业接触软纸尘与癌症发病率之间的关联.
- 为了确定高暴露水平是否会增加特定癌症的风险.
- 分析在软纸厂中不同长度就业的工人的癌症风险.
主要方法:
- 一项针对瑞典软纸厂7988名工人的队列研究 (1960-2008).
- 通过使用工作暴露矩阵,将工人分类为高 (>5 mg/m3>1年) 或低暴露于软纸尘.
- 癌症发病率追踪到2019年,并使用标准化发病率比率 (SIR) 与瑞典普通人口进行比较.
主要成果:
- 工作时间超过10年的高暴露工人显示结肠 (SIR 1.66),小肠 (SIR 3.27),甲状腺 (SIR 2.68) 和肺癌 (SIR 1.56) 的发病率增加.
- 暴露度较低的工人患有连接组织瘤 (肉瘤) (SIR 2.26) 和多叶层层层瘤 (SIR 3.29) 的发病率增加.
结论:
- 对软纸尘的高职业暴露与大肠和小肠瘤的发病率增加有关.
- 胸腔间皮瘤的风险增加很可能是由于接触了石棉,而增加肉瘤的原因尚不清楚.
- 需要进一步的研究来澄清纸尘与其他因素在观察到的癌症风险中的作用.
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