儿科IBD患者血清和肠道组织中的橄素
Vedrana Makevic1, Ivan D Milovanovich2, Nevena Popovac2
1Department of Pathological Physiology, Faculty of Medicine, University of Belgrade, Dr Subotica1, 11000 Belgrade, Serbia.
概括
这项研究在患有炎症性肠病 (IBD) 的儿童中发现了必需和有毒元素水平的显著差异. 血清和肠道组织中微量元素度的变化可能为IBD发展提供新的见解.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 环境健康 环境健康
- 微量元素分析 微量元素分析
背景情况:
- 炎症性肠病 (IBD) 的发病包括遗传,微生物,免疫和环境因素.
- 改变的微量元素水平在IBD中很常见,可能会影响疾病的发展.
- 升的IBD发病率与工业发展和重金属污染相关,涉及金属致病.
研究的目的:
- 在患有IBD的儿科患者中调查有毒和微量元素水平.
- 为了比较IBD患者和对照者的血清和肠道粘膜中的元素度.
主要方法:
- 对17名新诊断的儿科IBD患者 (10名克罗恩病 (CD),7名性结肠炎 (UC)) 和10名对照者的前性研究.
- 感应合等离子体质谱法 (ICP-MS) 用于测量13种元素 (Al,As,Ca,Cd,Cr,Cu,Fe,K,Mg,Mn,Na,Se,Zn) 的作用.
- 血清和肠道粘膜样本 (末端大肠,盲体,上升结肠,横结肠,下降结肠,西格结肠,直肠) 进行分析.
主要成果:
- 在IBD患者中观察到血清和肠道粘膜元素度的显著变化.
- 在IBD/CD中血清铁含量较低,在CD中血清铜含量较高,在UC亚组中血清含量最高.
- 肠道组织显示,终端结核中的Cu,Mg,Mn,Zn下降;阴中的Mg,Cu下降;横向结肠中的增加;西格结肠中的Mg下降.
- 在IBD和UC患者的结肠中,有毒元素 (Al,As,Cd) 减少.
结论:
- 在CD,UC和对照儿童中,Fe,Cu和Mn的血清含量显著不同,UC儿童的Mn含量最高.
- 肠道炎症患者在末端大肠中表现出减少的必要微量元素,并在结肠中减少的有毒元素.
- 调查宏观和微元素的变化为进一步了解IBD病原发生提供了潜力.
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