黑色素可以通过FOXO1信号通路缓解卵巢功能损伤和氧化应激,这种应激是德克萨米他在产母中引起的
Kang Bai1, Erying Hao1, Chen-Xuan Huang2
1College of Animal Science and Technology, Hebei Agricultural University, Baoding Hebei 071001, China.
Poultry science
|June 11, 2023
概括
黑素通过促进抗氧化酶和基因,减少细胞损伤,抑制FOXO1通路,从而保护生殖健康,减轻德甲诱导的氧化压力.
科学领域:
- 生殖生物学 生殖生物学
- 氧化压力研究研究 氧化压力研究
- 禽畜科学 禽畜科学 禽畜科学
背景情况:
- 氧化应激对家禽的毛囊发育和数量产生负面影响,减少生殖活动.
- 德克萨米他可靠地诱导的氧化压力,作为研究其影响的模型.
- 已知 Melatonin 对氧化应激的保护作用,但其在家禽繁殖中的具体机制尚不清楚.
研究的目的:
- 调查黑能否逆转甲诱导的产母母的氧化应激.
- 阐明美拉托尼在家禽毛囊中抗氧化应激的保护作用背后的特定分子机制.
主要方法:
- 150只产卵母被分为三个组:对照组 (盐水),德甲诱导的氧化应激,以及德甲 + 黑激素治疗.
- 治疗涉及30天内内内注射,第一个15天服用德克萨米他.
- 分析了关键的氧化应激标志物,抗氧化酶活动和基因表达,亡相关的基因和FOXO1通路.
主要成果:
- 德克萨米他显著增加了氧化应激标志物 (8-OHdG,MDA,ROS) 和亡.
- 黑色素治疗抑制了氧化应激,增强了抗氧化酶 (SOD,CAT,GSH-Px) 和相关基因表达 (CAT,SOD1,GPX3,PRDX3).
- 黑色素减少了亡的基因表达 (Caspase-3,Bim,Bax),增加了抗亡的Bcl-2,并抑制了FOXO1通路.
结论:
- 黑色素有效地对抗德克萨米他诱导的氧化应激和卵泡亡.
- 黑色素的保护机制涉及对抗氧化剂防御系统的上调和对FOXO1信号通路的下调.
- 这些发现突出了黑激素作为治疗剂的潜力,以改善在氧化应激条件下的家禽生殖健康.
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