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Updated: Jul 27, 2025

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由下调的AKT1-SKP2介导的免疫敏感性诱导了与抗PD-1相关的甲状腺免疫损伤

Yanmeizhi Wu1, Jingjing Li1, Xu Yang1

  • 1Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical University, PR China.

International immunopharmacology
|June 11, 2023
PubMed
概括

免疫检查点抑制剂如抗PD-1可以导致甲状腺免疫损伤. 这项研究确定了女性性别,甲状腺激素敏感性受损和IgG4作为危险因素,而抗PD-1降低了AKT1-SKP2的调节,以增加甲状腺免疫敏感性.

关键词:
一个AKT1一个AKT1抗PD-1病毒的使用.在CD8+T细胞中.在PD-L1中.在SKP2中,SKP2是SKP2.甲状腺炎症是什么

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