电子机械循环长度映射用于心房律乱检测和心脏转变成功评估
Melina Tourni1, Seungyeon Julia Han1, Rachel Weber1
1Depatrment of Biomedical Engineering, Columbia University, 630 W 168th Street, New York, 10032, NY, USA.
Computers in biology and medicine
|June 11, 2023
概括
机电循环长度映射 (ECLM) 非侵入地映射心房动 (AF) 激活,预测直流心脏转变 (DCCV) 的成功. 这种新的成像技术有助于个性化AF治疗,并评估复发风险.
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 电子生理学 电子生理学
背景情况:
- 直流心转 (DCCV) 是心房动 (AF) 的首要治疗方法,但复发率很高 (>70%).
- 现有的方法缺乏非侵入性的方法来评估DCCV的有效性和预测复发.
- 电子机械循环长度映射 (ECLM) 是一种用于非侵入性表征心脏激活的新技术.
研究的目的:
- 评估ECLM的可行性,用于绘制和量化心房节律失常电机激活率.
- 确定ECLM是否可以在1天和1个月的随访中提供DCCV的成功信息.
- 评估ECLM作为AF复发心转后预测工具的潜力.
主要方法:
- 45名受试者 (30名AF,15名对照) 在标准心声图视图中接受了胸前ECLM.
- AF患者在DCCV前和后立即进行成像,生成3D ECLM地图和周期长度 (CL) 组图.
- 计算的指标包括CL分散率和非节律性CLs (≤333ms) 的百分比.
主要成果:
- 在健康受试者中,ECLM准确证实了电动心房激活率 (R2=0.96).
- 在AF患者中,ECLM定位了DCCV前的不规则激活,并证实了DCCV后的成功转化.
- ECLM指标成功地将DCCV响应者与非响应者区分开来,并独立预测1个月AF复发.
结论:
- 在AF中,ECLM有效地描述和量化了机电激活率.
- 这种非侵入性模式可以识别和预测短期和长期AF复发.
- ECLM有助于量化AF严重程度,预测DCCV反应和个性化治疗计划.
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