相关实验视频

Updated: Jul 27, 2025

Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma

Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma

Published on: June 2, 2023

通过与TLE3相互作用,HHEX可以抑制晚期甲状腺癌

Zhongyun Xu¹, Yiyuan Feng¹, Yeqing Yan¹

¹Department of Nuclear Medicine, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, PR China.

Molecular and cellular endocrinology

|June 11, 2023

概括

在甲状腺癌中,血液发育表达的Homeobox (HHEX) 基因起到瘤抑制作用. 恢复HHEX表达可能为晚期甲状腺癌提供新的治疗策略.

科学领域:

内分泌学在内分泌学.
分子生物学分子生物学
在瘤学瘤学.

背景情况:

血液发育表达的家庭盒 (HHEX) 基因对甲状腺发育和分化至关重要.
在甲状腺癌中,HHEX通常被降低,但其确切的作用和机制尚未完全理解.

研究的目的:

为了研究HHEX在甲状腺癌中的功能.
阐明HHEX在甲状腺瘤发生和分化中的作用背后的分子机制.

主要方法:

在甲状腺癌细胞系中分析HHEX表达和局部化.
在体外和体内实验涉及HHEX敲击和过度表达的实验.
细胞增殖,迁移,入侵和同载体 (NIS) 活动的评估.
研究HHEX与TLE3蛋白和Wnt/β-catenin信号通路的相互作用.

主要成果:

发现甲状腺癌细胞中细胞质中HHEX的下调和异常局部化.
HHEX knockdown促进了,而过度表达抑制了癌细胞的增殖,迁移和入侵.
过度表达HHEX上调了NIS表达和促进剂活性,表明甲状腺分化增强.
HHEX调节TLE3蛋白水平,通过防止TLE3细胞质转移和无处不在,抑制Wnt/β-catenin信号传递.

结论:

在甲状腺癌中,HHEX作为瘤抑制剂起作用.
恢复HHEX表达可以抑制瘤的进展并促进分化.
准HHEX代表了晚期甲状腺癌的潜在治疗策略.

关键词:

晚期的甲状腺癌是什么?在HHEX中,它是HHEX.在TLE3中,有3个字母.在Wnt/β-catenin中使用.

更多相关视频

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Published on: August 23, 2019

相关概念视频

Synthesis and Regulation of Thyroid Hormones

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...