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卵巢癌中的PD-1/PD-L1免疫检查点阻塞:困境和机遇
Zikun Peng1, Ming Li1, Huayi Li1
1Department of Gynaecological Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; National Clinical Research Centre for Obstetrics and Gynaecology, Cancer Biology Research Centre (Key Laboratory of the Ministry of Education), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Drug discovery today
|June 11, 2023
概括
免疫检查点抑制剂 (ICI) 在卵巢癌中表现出有限的成功. 本综述审查了临床试验,耐药性机制和通过修改瘤微环境来提高ICI疗效的策略.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 癌症研究 癌症研究
背景情况:
- 免疫检查点抑制剂 (ICI) 已经改变了癌症治疗.
- 卵巢癌对ICI作为单一疗法或组合疗法的疗效较小.
- PD-1/PD-L1阻塞正在为卵巢癌进行调查.
研究的目的:
- 对卵巢癌中PD-1/PD-L1阻断的已完成和正在进行的临床试验进行审查.
- 在卵巢癌中对ICI耐药性的机制进行分类.
- 通过向瘤微环境,引入提高ICI疗效的策略.
主要方法:
- 在卵巢癌中使用PD-1/PD-L1抑制剂的临床试验的文献综述.
- 分析导致ICI耐药性的机制.
- 探索新的治疗方法来调节瘤微环境.
主要成果:
- 与其他恶性瘤相比,ICI在卵巢癌中表现出有限的疗效.
- 已经确定了对PD-1/PD-L1阻断的抵抗的几种机制.
- 正在制定克服阻力和加强ICI活动的策略.
结论:
- 卵巢癌仍然是当前ICI疗法的挑战.
- 了解抵抗机制对于开发有效的治疗方法至关重要.
- 调节瘤微环境有望改善对PD-1/PD-L1抗体的反应.
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