巨细胞破坏了食道上皮屏障的功能
Mirelle T A Kleuskens1, Marie K Bek1, Youmna Al Halabi1
1Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
Mucosal immunology
|June 11, 2023
概括
巨细胞 (MCs) 恶化了性食道炎 (EoE) 中的食道屏障. 激活的MC增加了透性并降低了屏障蛋白,可能是通过代M (OSM) 来实现的.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
背景情况:
- 性食道炎 (EoE) 涉及食道炎症和屏障功能障碍.
- 巨细胞 (MCs) 透到EoE患者的上皮.
- 缺陷的食道上皮屏障功能是EoE的一个关键特征.
研究的目的:
- 为了研究巨细胞 (MCs) 在危害食道上皮质屏障功能的作用,在eosinophilic食道炎 (EoE).
- 为了确定参与MC诱导的屏障功能障碍的潜在调解者.
主要方法:
- 分化食道上皮细胞与活性和非活性乳腺细胞 (MCs) 的共同培养.
- 测量上皮质的抗性和透性.
- 屏障蛋白mRNA表达的分析.
- 有针对性的蛋白质组学来识别细胞因子.
- 通过哥斯塔丁M (OSM) 刺激上皮细胞.
主要成果:
- 激活的MCs显著降低了上皮抵抗力和提高了透性.
- 屏障蛋白mRNA表达 (filaggrin,desmoglein-1,involutrin) 被降低了. 这是一个很好的例子.
- 确定了哥斯塔丁M (OSM) 作为一个关键的细胞因子,其活性EOE的表达增加.
- OSM刺激上皮细胞的剂量依赖性障碍障碍功能和改变的蛋白质表达.
结论:
- 乳腺细胞 (MCs) 导致食道上皮质屏障功能障碍在性食道炎 (EoE).
- Kostatin M (OSM) 可能是MC诱导的屏障损伤的关键调解者.
- 这些发现突出了EoE病变发生的新机制.
相关概念视频
Barrett Esophagus-I: Introduction
136
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
136
Mucosal Barrier of the Stomach
721
The gastric glands contain parietal cells that secrete hydrochloric acid (HCl) for digestion. The cells secrete HCl because it is highly corrosive and essential for breaking down food. To achieve this, they secrete hydrogen and chloride ions into the lumen of the gastric glands, which combine to form HCl.
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
721
Esophageal Strictures-I: Introduction
175
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
175
Barrett Esophagus-II: Clinical Manifestations and Management
218
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
218
Esophageal Perforation-I: Introduction
133
Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
133
Esophagus
1.0K
The esophagus, a muscular conduit linking the pharynx and stomach, measures roughly 10 inches (25.4 cm) and sits behind the trachea. It remains collapsed when not swallowing. The esophagus follows a predominantly straight path through the thoracic mediastinum and enters the abdominal cavity through a diaphragmatic opening known as the esophageal hiatus.
The movement of edibles from the pharynx into the esophagus is facilitated by the upper esophageal sphincter, which is formed primarily by the...
The movement of edibles from the pharynx into the esophagus is facilitated by the upper esophageal sphincter, which is formed primarily by the...
1.0K


