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Basophil Activation Test for Allergy Diagnosis

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基细胞激活测试在双重敏感的患者与黄虫毒素过敏:组件解决诊断的额外好处

Paul Schmidle¹, Simon Blank², Sabine Altrichter³

¹Department of Dermatology and Allergy Biederstein, School of Medicine, Technical University of Munich, Munich, Germany.

The journal of allergy and clinical immunology. In practice

|June 11, 2023

概括

使用特定毒素成分的基细胞激活测试 (BAT) 有助于识别黑虫毒素过敏的罪祸首昆虫,指导毒素免疫疗法 (VIT) 的决策. 在整个毒素测试不清楚时,组件解决的诊断提高了准确性.

科学领域:

过敏和免疫学过敏和免疫学
昆虫毒过敏昆虫毒过敏
诊断测试诊断测试诊断测试

背景情况:

鉴定特定的昆虫过敏原是挑战在患有黄虫毒素过敏的患者,特别是那些对多种毒素敏感的人.
准确的诊断对于确定适当的毒素免疫疗法 (VIT) 至关重要.

研究的目的:

评估使用毒液提取物和单个成分的基基细胞激活试验 (BAT) 在区分过敏和敏感个体中的有用性.
评估如何BAT结果影响医生对双重敏感患者VIT的决定.

主要方法:

在31名患有对蜜蜂和黄蜂毒素血清双重敏感的患者进行了BAT测试.
测试使用整个毒液提取物和特定组件:Api m1,Api m10,Ves v1和Ves v5.

主要成果:

组件解决的BAT在几个情况下提供了更清晰的诊断信息,其中整个毒液提取物没有确定性.
像Ves v5,Api m1和Api m10这样的特定成分在识别相关过敏原方面特别有用.
在21/28例患者中,VIT建议仅使用黄蜂毒,在1/28例患者中仅使用蜜蜂毒,在4/28例患者中使用两种毒.

结论:

组件解决的BAT,特别是Ves v5,Api m1和Api m10,有助于在28.6%的患者中选择VIT的正确昆虫.
对于从全毒素提取物测试中得到模两可的结果的情况,建议使用额外的组件解决的BAT.

关键词:

艾比姆是一只.子 m 10 10 的时间.基细胞激活试验黄虫的毒液过敏过敏的过敏分子过敏原是分子的过敏原.毒药免疫疗法是一种毒药免疫疗法.在VES v 1 1中使用.在5月5日晚上.

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