SOHO 最新技术更新和下一个问题 罕见T细胞淋巴瘤的挑战性病例
Rahul S Bhansali1, Stefan K Barta1
1Department of Medicine, Division of Hematology and Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA.
Clinical lymphoma, myeloma & leukemia
|June 11, 2023
概括
成熟的T细胞和NK细胞新生瘤 (MTNKN) 是一种罕见的,异质的淋巴细胞疾病. 本综述侧重于罕见的亚型,强调这些不常见的非霍奇金淋巴瘤病例的诊断和管理策略.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 成熟的T细胞和NK细胞新生瘤 (MTNKN) 是罕见的,占非霍奇金淋巴瘤 (NHL) 病例的<15%.
- 这些瘤包括9个世卫组织分类家族的30多个亚型,表现出显著的异质性.
- 5种最常见的亚型占MTNKN的75%以上,留下许多较罕见的亚型,诊断和管理共识有限.
研究的目的:
- 审查罕见的成熟T细胞和NK细胞瘤.
- 突出特定罕见亚型的临床和诊断特征.
- 讨论这些罕见实体的当前管理选择.
主要方法:
- 文献综述侧重于特定的罕见MTNKN亚型.
- 综合临床,诊断和管理信息.
- 重点是包括EATL,MEITL,HSTCL,SPTCL和PCGD-TCL在内的实体.
主要成果:
- 详细的临床表现和诊断标准的详细概述为选择的罕见MTNKN.
- 讨论这些罕见的T细胞和NK细胞恶性瘤中的异质性.
- 探索可用的治疗策略和管理中的挑战.
结论:
- 罕见的MTNKN亚型由于其不常见,因此存在独特的诊断和治疗挑战.
- 对这些罕见实体进行专注的审查对于改善患者护理至关重要.
- 需要进一步的研究和达成共识,以优化罕见的T细胞和NK细胞瘤的治疗.
更多相关视频
06:08Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model
Published on: February 10, 2023
1.4K
09:08Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
Published on: October 14, 2021
5.5K
相关概念视频
Treatment Resistant Cancers
3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
Tumor Immunotherapy
575
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
575
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
T Cell Activation and Clonal Selection
837
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
837
![Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F62334.jpg&w=3840&q=50)