由L. monocytogenes引起的脑炎的流行病学,临床和成像特征. 一个回顾性观察性研究
A J Láinez-Ramos Bossini1,2, P Redruello-Guerrero3,2, J P Martínez-Barbero1,2
1Hospital Universitario Virgen de las Nieves, Granada, España.
Revista de neurologia
|June 12, 2023
概括
列斯特病患者的罗姆脑炎与较高的死亡率有关. 关键的MRI发现包括T2-FLAIR高强度和子,骨髓和小脑的增强,有助于诊断.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 放射学 放射学是一门学科.
背景情况:
- 李斯特病可以导致罗姆脑炎,这是一个严重的神经复杂症.
- 有限的数据存在于特定的风险因素,成像和临床症状的 listeriosis-associated rhombencephalitis.
研究的目的:
- 为了分析Listeria monocytogenes rhombencephalitis的成像发现.
- 为了确定受影响患者的常见MRI特征和解剖参与.
主要方法:
- 李斯特菌病病例的回顾性观察研究 (2008-2021年).
- 收集了有关风险因素,并发症,临床结果,症状和MRI发现的罗姆脑炎患者的数据.
- 进行了描述性和双变量分析.
主要成果:
- 在120名李斯特菌病患者中,有10名 (8.3%) 患有罗姆脑炎.
- 常见的MRI发现:T2-FLAIR高强度 (100%),T1低强度 (80%),表细胞增强 (80%),神经增强 (70%).
- 受影响最多的区域:小,长髓,小脑. 并发症包括,出血和脑水.
结论:
- 罗姆脑炎显著增加了列菌病患者的住院死亡率.
- 神经化病的特定解剖分布和成像模式可以表明诊断.
- 需要对更大的队列进行进一步的研究,以关联成像,位置,并发症和结果.
相关概念视频
01:24Bacterial Meningitis
Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
01:18Viral Meningitis
Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
01:28Rabies
Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...
01:22Bacterial Meningitis I: Introduction
Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
01:19Encephalitis l: Introduction
Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
01:26Encephalitis ll: Pathophysiology
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...