粘粘性离子液体凝贴片用于口服输送
Kevin Peng1,2, Yujie Shi1, Anthony LaBarbiera1
1John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States.
ACS biomaterials science & engineering
|June 12, 2023
概括
离子液体 (ILs) 和深溶剂 (DESs) 像CAGE,当被封装在粘粘性离子凝贴片 (CAGE贴片) 中时,通过改善胰岛素的肠道吸收来显著增强口服药物输送.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 胃肠道药理学 胃肠道药理学
背景情况:
- 通过口服输送的生物药物面临着巨大的挑战,因为胃肠道 (GI) 的固有障碍.
- 离子液体 (ILs) 和深溶剂 (DESs),如胆和石榴 (CAGE),有望改善治疗药物的肠道吸收.
- 在肠道内定位输送剂可以通过增加局部药物度和最大限度地减少全身暴露来优化治疗效果.
研究的目的:
- 开发一种新型的粘粘性离子凝贴片 (CAGE-patch),用于局部向肠道输送CAGE和治疗药物.
- 评估CAGE贴片的粘粘性,胀行为和受控释放特征.
- 评估CAGE贴片在增强胰岛素肠道运输方面的有效性.
主要方法:
- 将CAGE封装在聚乙醇 (PVA) 凝基质中,以使用冷解周期形成粘粘性离子凝贴片 (CAGE贴片).
- 描述CAGE补丁的特性,包括粘膜粘附,胀和药物释放动力学.
- 在体外运输研究使用Caco-2和HT29-MTX-E12共同培养模型来评估胰岛素透.
主要成果:
- CAGE贴片表现出显著的粘粘性强度,受控的胀和持续释放的CAGE和胰岛素.
- 在体外研究表明,与对照组相比,胰岛素在肠道细胞层中的运输增加了30%以上.
- 开发的离子凝系统有效地将IL和治疗药物定位在模拟的肠道环境中.
结论:
- 粘粘性CAGE贴片代表了局部口服输送IL和胰岛素等治疗剂的新有效策略.
- 这种方法增强了肠道吸收,并通过优化肠道内的药物局部化来改善治疗窗口.
- CAGE-patch技术在促进口服生物药物输送方面具有重大潜力.
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